Chronic diarrhea

Chronic diarrhea

Who's the Murphy guy?

John Benjamin Murphy

Cellular adaptation

Adaptation..according to the spectrum of cellular response (the term 'spectrum' is kinda addictive).. A cellular adaptation is a homeostasis (which means maintained steady state) but at new physiologic level, compatible with the presence of stressors.

It's like the fever...mostly, people would confidently says that it is due to TNF and IL-1 and that is it. WHEREAS, in actual, these two mediators increase the enzymes (cyclooxygenases) that convert AA into prostaglandins.In the hypothalamus, the prostaglandins, especially PGE2, stimulate the production of neurotransmitters such as cyclic AMP, which function to reset the temperature set-point at a higher level..Endogenous pyrogens.djeah!

Anyways..cellular adaptation
1.Hypertrophy
2.Hyperplasia
  -physiologic
     +hormonal (as in menstruation)
     +compensatory
  -pathologic
3.Atrophy
  -work
  -innervation
  -blood supply
  -nutrition (as in cancer patient..cachexic!TNF (TNF) is thought to be responsible for appetite suppression and muscle atrophy. (robbins)
  -endocrine stimulation (endocrine gland, breast, reproductive organ)now i wonder why breast and reproductive organ isnt under one category]
  -senile
  -pressure (it'll cause compression of vessels/nerve)
4.Metaplasia

1st year debut.

But... Parenchyma (P) and Interstitial tissue (I) plays role upon any insult to cause injury... Changes in I can disrupt P and vice versa.